Gene information
Official symbol PGF
Official full name placental growth factor
Gene type protein-coding gene
Chromosome14q24.3
Alias symbolPlGF-2; SHGC-10760; D12S1900; PIGF; PLGF; PlGF
Previous symbolPGFL
Gene familyVEGF family
Resources
Entrez Gene 5228
HGNC HGNC:8893
Ensembl ENSG00000119630
Vega OTTHUMG00000171496
UCSC uc001xqz.4
GO terms: 63 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005172 vascular endothelial growth factor receptor binding GO Molecular Functions -3.72261873 5 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035924 cellular response to vascular endothelial growth factor stimulus GO Biological Processes -8.07167727 14 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0038084 vascular endothelial growth factor signaling pathway GO Biological Processes -6.53278734 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0048010 vascular endothelial growth factor receptor signaling pathway GO Biological Processes -5.65848894 6 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0050926 regulation of positive chemotaxis GO Biological Processes -15.5115450 16 More
GO:0050927 positive regulation of positive chemotaxis GO Biological Processes -14.3403642 15 More
GO:0050930 induction of positive chemotaxis GO Biological Processes -11.6499260 8 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051302 regulation of cell division GO Biological Processes -3.83250874 20 More
GO:0051781 positive regulation of cell division GO Biological Processes -5.46648014 9 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 3 records
Drug name Interaction type Source PMID View
aflibercept binderinhibitor ChemblInteractionsTTD 22813448 view
conbercept inhibitor ChemblInteractions view
tb-403 TdgClinicalTrialTTD view
Related studies: 6 records
Molecular factor Omics type Application Objective MI type Reference
placenta growth factor proteomics left ventricular ejection fraction[other] acute myocardial infarction Iwama H et al. J Am Coll Cardiol. 2006
placenta growth factor proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kodama Y et al. J Am Coll Cardiol. 2006
placenta growth factor proteomics atorvastatin[treatment (pharmacotherapy)] acute myocardial infarction Kodama Y et al. J Am Coll Cardiol. 2006
placenta growth factor proteomics death[prognosis (bad)] acute non-ST elevation myocardial infarction Markovic M et al. South Med J. 2010
placenta growth factor proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Hochholzer W et al. Eur Heart J. 2011
placenta growth factor proteomics death[prognosis (bad)] acute myocardial infarction Hochholzer W et al. Eur Heart J. 2011
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